Protein Purification Services
Fina BioSolutions protein purification services help small biotech companies move from discovery to early clinical trials. We specialize in developing protein purification/downstream processing protocols for laboratory-scale and process scale-up.
Protein Purification Outsourcing. We can purify your diagnostic or therapeutic protein, including antibodies and enzymes. Our mixed-mode protein chromatography expertise offers efficient capture and purification with a minimum number of steps.
Development of Protein Purification/Downstream Processes for Scale-Up. Proceed to Phase I/II manufacturing through our alliances with the University of Maryland BioProcessing Scale-up Facility (BSF) and the Center for Advanced Research in Biotechnology (CARB) GMP facility in Rockville, Maryland.
Downstream Process Troubleshooting. We can review and revise your current protocols to help you develop a robust purification process that runs with minimal variation.
Protein Expression
Protein Expression Optimization and Fermentation. Through our partners we can optimize protein expression and fermentation media and generate your raw cell mass for protein purification. We offer bacterial fermentations from 1 to 200 liters. Yeast and mammalian cell fermentations are available also.
Bioconjugation Services
Bioconjugation creates essential reagents for many diagnostic assays, particularly ELISAs. We are noted for our work in conjugate vaccines. More than 30 years experience.
Bioconjugation Specialties:
- Anti-Ig dextran conjugates
Reference: J. Immunol. 157: 2229 (1996); C. M. Snapper and J. J. Mond. “A model for induction of T cell-independent humoral immunity in response to polysaccharide antigens” - Protein-carbohydrate conjugates for conjugate vaccines
Reference: Vaccine 2006 24:716-29. - Peptide conjugates to enhance binding and detection for ELISAs
- Amino-dextran, size fractionated (Am dex). Amino dextran prepared according to Inman JK. J Immunol. 114:704-9, 1975 is size fractionated to provide a more homogeneous product.
Other Bioconjugation Services Include:
- Antibody and protein biotinylation and fluorescent labeling
- Antibody-enzyme conjugates and other protein-protein linkages
- Conjugations for peptide immunogens and vaccines
- Conjugations with hydrophobic peptides.
- Pegylation
Conjugate Vaccines. We have decades of experience in conjugate vaccines and proprietary chemistry for preparing carbohydrate conjugate vaccines. One of our inventions licensed by GlaxoSmithKline underlies the chemistry of their pediatric conjugate vaccines Menitorix and Synflonix.
Protein Conjugate Vaccine Patent Consulting. Protein conjugate vaccine patents constitute a vast body of prior art. We can help conjugate vaccine makers determine what is an innovation and what is not.
Immunoassay Design & Antibodies
These services are offered through our affiliate Antibody and Immunoassay Consultants, LLC.
Immunoassays. We design and validate immunoassays according to client production requirements. We can also make reagents to minimize the number of immunoassay steps.
Antibody Production Services
- Murine monoclonal antibodies
- Murine and rabbit polyclonal antibodies