Webinar: Enhancing Process Economics and Improving Product Purity
Fina BioSolutions announces an upcoming webinar:
Title: Enhancing Process Economics and Improving Product Purity
Date: Thursday, September 24, 2009
Time: 2:00 PM - 3:00 PM EDT
Space is limited - reserve your Webinar seat now.
After registering you will receive a confirmation email containing
information about joining the Webinar.
A presentation and discussion led by:
- Andrew Lees PhD, Scientific Director, Fina Biosolutions, LLC
- Warren Schwartz PhD, Senior Techinical Director, Pall Life Sciences
- High-Productivity Ion Exchange Sorbents with Distinctive Selectivity Characteristics
- Advances in Strategies and Materials for Purification of Monoclonal Antibodies
The drive for higher titer cell culture processes is adding pressure to the chromatographic steps in the downstream process and the development of novel, industry scalable chromatographic products, capable of dealing with these challenges, is ongoing. New additions to the chromatographic toolbox will be presented here that will enhance process productivity, increase throughput and help reduce processing costs.
In current practice, conventional strategies for monoclonal antibody purification provide product of clinically-required purity in commercially practical yields. In most cases, purification schemes begin with affinity chromatography on a Protein-A sorbent followed by two additional chromatographic steps, usually a combination of cation exchange, anion exchange or hydrophobic interaction chromatography. Having advanced the art to this state of technical maturity, process developers are increasingly looking toward strategies and techniques to materially enhance the practical efficiency and process economics of the overall purification scheme, while maintaining required product quality.
This seminar will include examination of studies that describe the evaluation of novel chromatographic sorbents and membrane chromatography products, where the explicitly stated research objectives include enhanced process economics and practical improvements in process flow. Materials and techniques to be examined during the seminar include:
- Enhanced-diffusion ion exchange for capture applications
- Hydrophobic charge induction chromatography sorbent for both capture and polishing steps
- Anion exchange on membrane chromatography products for polishing steps